Identification of metastasis-associated genes by transcriptional profiling of a metastasizing versus a non-metastasizing human melanoma cell line

Autor:	R, Brem, T, Hildebrandt, M, Jarsch, G N, Van Muijen, U H, Weidle
Rok vydání:	2001
Předmět:	Mice Inbred BALB C Transcription Genetic Down-Regulation Blotting Northern Up-Regulation Gene Expression Regulation Neoplastic Mice Phenotype Tumor Cells Cultured Animals Humans RNA Messenger Neoplasm Metastasis Melanoma Neoplasm Transplantation Oligonucleotide Array Sequence Analysis
Zdroj:	Anticancer research. 21(3B)
ISSN:	0250-7005
Popis:	In order to identify genes associated with the metastatic phenotype we have compared the expression pattern of 6800 genes in a metastatic (NMCL-1) versus a non-metastatic (530) human melanoma cell line making use of DNA microarrays. The differentially expressed genes identified are involved in control of transcription, regulation of the cell-cycle, proteolysis, cell adhesion, immune response and signaling. A remarkable feature of the system under investigation is the consistent down-regulation of MHC-related and cell adhesion mediating genes in the metastatic cell line.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b269dd324b73419e5e61f01e1cc787bc https://pubmed.ncbi.nlm.nih.gov/11497253 Zobrazit plný text záznamu