| Autor: |
Jie, Yang, Yong-Bin, Yang, Rui-Cang, Wang, Jing-Yue, Liu, Yan, Li, Jun, Yuan, Jie, Li, Xiao-Xia, Zhang, Xiao-Han, Gao, Hong-Ling, Hao |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 30(6) |
| ISSN: |
1009-2137 |
| Popis: |
To investigate the characteristics of gene mutation, clinical characteristics and significance in acute leukemia (AL) patients.The clinical data of 102 AL patients in Hebei General Hospital from September 2016 to September 2020 were collected and analyzed retrospectively, including the characteristics of gene mutation, age, peripheral blood cells, bone marrow blasts, leukemia subtypes and myeloperoxidase (MPO).The total gene mutation rate was 87.25% (89/102) in all 102 patients. A total of 275 gene mutations were detected, with an average of 2.70 gene mutations per patient. The most frequent mutations of 102 patients were as follows:The incidence of gene mutation in patients with AL is high, and it often occurs simultaneously.急性白血病患者基因突变与临床特征分析.探讨急性白血病（AL）患者基因突变特点及其临床特征和意义.回顾性分析2016年9月至2020年9月河北省人民医院收治的102例初诊AL患者基因突变特点，以及患者年龄、外周血细胞、原始细胞、白血病FAB分型、髓过氧化物酶（MPO）表达等临床特征.102例AL患者中，基因突变阳性89例（87.25%）。共检测到275次基因突变，平均每例患者发生2.70个基因突变。突变检出率由高到低依次为AL患者基因突变发生率较高，且常伴随出现。 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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