Effects of phenytoin on cocaine self-administration in humans

Autor:	M, Sofuoglu, P R, Pentel, R L, Bliss, A I, Goldman, D K, Hatsukami
Rok vydání:	1999
Předmět:	Adult Male Analysis of Variance Cocaine-Related Disorders Patient Dropouts Phenytoin Surveys and Questionnaires Crack Cocaine Humans Anticonvulsants Female Self Administration Middle Aged
Zdroj:	Drug and alcohol dependence. 53(3)
ISSN:	0376-8716
Popis:	The goal of this pilot study was to determine the effects of phenytoin on cocaine self-administration in a human laboratory model. Subjects were randomized to either phenytoin (n = 6) or placebo (n = 7). Those assigned to phenytoin treatment received a single oral loading dose of 20 mg/kg. The phenytoin and placebo treatment groups did not differ in the number of tokens valued at $5, exchanged for cocaine. Similarly, the cardiovascular and subjective response to cocaine administration did not show a statistically significant treatment effect. In this laboratory model, phenytoin did not alter either the self-administration or effects of cocaine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b226be11dc6de72a941ff5164a4cb6f5 https://pubmed.ncbi.nlm.nih.gov/10080053 Zobrazit plný text záznamu Full Text from ScienceDirect