| Autor: |
H J, Thompson, K C, Westerlind, J, Snedden, S, Briggs, M, Singh |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Carcinogenesis. 16(8) |
| ISSN: |
0143-3334 |
| Popis: |
The objective of this experiment was to evaluate the effects of treadmill exercise on tumor induction in an experimental model for breast cancer. Female F-344 rats were injected i.p. with 50 mg MNU/kg body wt at 50 and 57 days of age. Animals were assigned to one of five groups: sham exercise or 35% or 70% maximal treadmill running intensity for 20 or 40 min/day, 5 days per week. These work rates represent an exercise intensity level generally considered insufficient to improve cardiovascular fitness (35% maximal intensity) or an aerobic level of exercise sufficient to improve cardiovascular fitness in humans (70% maximal intensity). Rats were exercised for 3 months following carcinogen administration at which time the experiment was terminated. Mammary cancer incidence was reduced by as much as 37% and cancer multiplicity by60% at the highest exercise intensity. Unexpectedly, the degree of protection against cancer was proportional to the intensity but not to the duration of exercise. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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