Immunosuppressive antimetabolites inhibit induction of contact hypersensitivity while lymphoablative drugs also prevent its expression
| Autor: | Laurence, Quéméneur, Marie-Cécile, Michallet, Carole, Ferraro-Peyret, Pierre, Saint-Mézard, Josette, Benetière, Marie-Thérèse, Ducluzeau, Jean-François, Nicolas, Jean-Pierre, Revillard |
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| Rok vydání: | 2004 |
| Předmět: |
Mice
Inbred BALB C Antimetabolites Antineoplastic Agents Apoptosis CD8-Positive T-Lymphocytes Mycophenolic Acid Mice Methotrexate Cell Movement Langerhans Cells Dermatitis Allergic Contact Animals Dinitrofluorobenzene Female Fluorouracil Lymphocytes Mitoxantrone Cyclophosphamide Cells Cultured Immunosuppressive Agents |
| Zdroj: | European journal of dermatology : EJD. 13(6) |
| ISSN: | 1167-1122 |
| Popis: | Contact hypersensitivity is one of the most common skin diseases and its pharmacological control is an important clinical issue. We investigated the control of contact hypersensitivity by immunosuppressive drugs administered during sensitization or challenge. Mycophenolate mofetil, methotrexate and 5-fluorouracil completely inhibited contact hypersensitivity when administered during sensitization whereas they did not decrease inflammatory reaction when administered during challenge. Conversely, mitoxantrone, and cyclophosphamide, given as a single injection at the time of sensitization or challenge, completely inhibited the reaction, a property associated with T and B cell depletion. The data indicate that antimetabolites which are cell cycle dependent inhibit clonal expansion and subsequent differentiation of cytotoxic CD8+ T cells. Their lack of effect at the time of challenge indicates that T cell proliferation is not required for the expression of effector or regulatory T cell activation. Conversely lymphoablative drugs can inactivate or destroy differentiated cytotoxic T cells with rapid kinetics. |
| Databáze: | OpenAIRE |
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