Prenatal exposure to PCBs in Cyp1a2 knock-out mice interferes with F
| Autor: | Jillian R, Hufgard, Jenna L N, Sprowles, Emily M, Pitzer, Sheryl E, Koch, Min, Jiang, Qin, Wang, Xiang, Zhang, Jacek, Biesiada, Jack, Rubinstein, Alvaro, Puga, Michael T, Williams, Charles V, Vorhees |
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| Rok vydání: | 2018 |
| Předmět: |
Mice
Knockout Reflex Startle Conditioning Classical Long-Term Potentiation Motor Activity Polychlorinated Biphenyls Mice Inbred C57BL Mice Fertility Cytochrome P-450 CYP1A2 Pregnancy Prenatal Exposure Delayed Effects Animals Environmental Pollutants Female Maze Learning CA1 Region Hippocampal Spatial Memory |
| Zdroj: | Journal of applied toxicology : JAT. 39(4) |
| ISSN: | 1099-1263 |
| Popis: | Polychlorinated biphenyls (PCBs) are toxic environmental pollutants. Humans are exposed to PCB mixtures via contaminated food or water. PCB exposure causes adverse effects in adults and after exposure in utero. PCB toxicity depends on the congener mixture and CYP1A2 gene activity. For coplanar PCBs, toxicity depends on ligand affinity for the aryl hydrocarbon receptor (AHR). Previously, we found that perinatal exposure of mice to a three-coplanar/five-noncoplanar PCB mixture induced deficits in novel object recognition and trial failures in the Morris water maze in Cyp1a2 |
| Databáze: | OpenAIRE |
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