Identification of three new DRB1 alleles, DRB1*0107, *0425 and *13012 and confirmation of DRB4*01033

Autor:	C E M, Voorter, B G, Hepkema, S P M, Lems, E M, van den Berg-Loonen
Rok vydání:	2003
Předmět:	HLA-D Antigens Base Sequence Sequence Homology Amino Acid Molecular Sequence Data Exons HLA-DR Antigens Polymerase Chain Reaction Sequence Homology Nucleic Acid HLA-DR4 Antigen Humans Amino Acid Sequence Alleles Polymorphism Single-Stranded Conformational HLA-DRB1 Chains
Zdroj:	Tissue antigens. 61(5)
ISSN:	0001-2815
Popis:	The characterization of three novel DRB1 alleles is described, DRB1*0107, DRB1*0425 and DRB1*13012 as well as confirmation of DRB4*01033. Two alleles, DRB1*0107 and *0425, showed amino acid differences with previously identified HLA molecules. In DRB1*0107, the glutamine at position 10 was substituted by a glutamic acid. DRB1*0425 showed one amino acid difference with DRB1*0418 (I to F) at position 67, and five amino acid differences with DRB1*04011 at positions 67 (L to F), 70 (Q to D), 71 (K to R), 74 (A to L) and 86 (G to V). The alleles DRB1*13012 and DRB4*01033 had protein sequences identical to DRB1*13011 and DRB4*01031/01032, respectively. Nucleotide differences were present at position 306 for DRB1*13012 and at position 321 for DRB4*01033.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b1ddcd814256b6f1229c895e89328019 https://pubmed.ncbi.nlm.nih.gov/12753659 Zobrazit plný text záznamu Plný text ve formátu PDF