| Autor: |
W, Naumnik, M, Ossolińska, I, Płońska, E, Chyczewska, J, Nikliński |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Advances in experimental medicine and biology. 833 |
| ISSN: |
0065-2598 |
| Popis: |
Thrombospondin-2 (TSP-2) is an endogenous negative regulator of vascularization in human cancer. TSP-2 regulates angiogenesis through binding and sequestration of the proangiogenic fibroblast growth factor-2 (FGF-2). However, it is unclear whether TSP-2 and FGF-2 are related to prognosis in non-small cell lung cancer (NSCLC). To study this issue, we measured serum (Elisa) levels of TSP-2 and FGF-2 in 40 NSCLC patients (before chemotherapy) and 22 healthy subjects. Both TSP-2 and FGF-2 concentrations were elevated in the NSCLC group compared with control (TSP-2: 26.72±8.00 vs. 18.64±5.50 ng/ml, p=0.002; FGF-2: 11.90±5.80 vs. 7.26±3.90 pg/ml, p=0.01). Receiver-operating characteristic (ROC) curves were applied to find the cut-off serum levels of TSP-2 and FGF-2 (NSCLC vs. healthy: TSP-2=15.09 ng/ml, FGF-2=2.23 pg/ml). Patients before treatment with the TSP-2 level24.15 ng/ml had a median survival of 23.7 months, but those with TSP-224.15 ng/ml had only 9 months' median survival (p=0.007). Patients with FGF-2 level11.21 pg/ml had significantly shorter survival than patients with FGF-211.21 pg/ml (7.5 months vs. 16 months, p=0.034). We conclude that NSCLC patients have higher serum concentrations of TSP-2 and FGF-2 than healthy people. High levels of TSP-2 and FGF-2 may predict worse survival. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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