[Correction of endothelial dysfunction by L-arginine under experimental pre-eclampsia conditions]

Autor:	M V, Pokrovskiĭ, T G, Pokrovskaia, V V, Gureev, A A, Barsuk, E V, Proskuriakova, M V, Korokin, O S, Gudyrev, A S, Belous, V I, Kochkarov, L M, Danilenko, O V, Levashova, N V, Mal'tseva, O S, Polianskaia
Rok vydání:	2012
Předmět:	Nitric Oxide Synthase Type III Microcirculation Placenta Blood Pressure Arginine Rats NG-Nitroarginine Methyl Ester Pre-Eclampsia Pregnancy Hypertension Albuminuria Animals Humans Female Endothelium Injections Intraperitoneal
Zdroj:	Eksperimental'naia i klinicheskaia farmakologiia. 75(2)
ISSN:	0869-2092
Popis:	The ADMA-like pre-eclampsia in pregnant rats was modeled by daily introduction of L-NAME in a dose of 25 mg/kg for 7 days. L-arginine (200 mg/kg) prevented the development of arterial hypertension and a decrease in placentary microcirculation and microalbuminuria. The possibility of using L-arginine for the prevention of competitive eNOS inhibition by ADMA is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b1a4aea555954e5bdbeb16f2712ce20b https://pubmed.ncbi.nlm.nih.gov/22550853 Zobrazit plný text záznamu