| Autor: |
E I, Boreko, N I, Pavlova, V I, Votiakov |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Voprosy virusologii. 44(3) |
| ISSN: |
0507-4088 |
| Popis: |
A variant obtained by a single passage of the initial FPV in the presence of 25 micrograms/ml rimantadine is more resistant to the drug than the parental virus. Sensitivity to rimantadine is higher in a variant obtained similarly by cell culture infection with rimantadine-resistant FPV. Potentiation of the antiviral effect of a combination of ribavirin (12-25 micrograms/ml) and rimantadine (0.1-6 micrograms/ml) is decreased or null if rimantadine dose is increased to 12-25 micrograms/ml; this phenomenon does not depend on the sensitivity of infective virus to rimantadine. Antiviral effect of drug combination with a high concentration of rimantadine is due to ribavirin alone. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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