Elevated serum homocysteine levels and increased risk of invasive cervical cancer in US women
| Autor: | S J, Weinstein, R G, Ziegler, J, Selhub, T R, Fears, H D, Strickler, L A, Brinton, R F, Hamman, R S, Levine, K, Mallin, P D, Stolley |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Colorado Uterine Cervical Neoplasms Enzyme-Linked Immunosorbent Assay Risk Assessment Predictive Value of Tests Risk Factors Odds Ratio Humans Neoplasm Invasiveness Homocysteine Papillomaviridae Chromatography High Pressure Liquid Neoplasm Staging Papillomavirus Infections Middle Aged Pennsylvania Vitamin B 6 Tumor Virus Infections Vitamin B 12 Case-Control Studies Alabama Florida Regression Analysis Female Illinois |
| Zdroj: | Cancer causescontrol : CCC. 12(4) |
| ISSN: | 0957-5243 |
| Popis: | To explore the relationship between serum homocysteine, a sensitive biomarker for folate inadequacy and problems in one-carbon metabolism, and invasive cervical cancer.A large case-control study was conducted in five US areas with up to two community controls, obtained by random-digit dialing, individually matched to each case. Cervical cancer risk factors were assessed through at-home interview. Blood was drawn at least 6 months after completion of cancer treatment from 51% and 68% of interviewed cases and controls. Serum homocysteine was measured by high-performance liquid chromatography, and exposure to human papillomavirus (HPV) type 16, the most prevalent oncogenic type, was assessed using an enzyme-linked immunosorbent assay. Cases with advanced cancer and/or receiving chemotherapy were excluded, leaving 183 cases and 540 controls.Invasive cervical cancer risk was substantially elevated for women in the upper three homocysteine quartiles (6.31 micromol/L); multivariate-adjusted odds ratios ranged from 2.4 to 3.2 (all 95% CIs excluded 1.0). A trend was apparent and significant (p = 0.01). When cases were compared with HPV-16 seropositive controls only, odds ratios were comparable.Serum homocysteine was strongly and significantly predictive of invasive cervical cancer risk. This association could reflect folate, B12 and/or B6 inadequacy, or genetic polymorphisms affecting one-carbon metabolism. |
| Databáze: | OpenAIRE |
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