Sequencing [4 + 1]-Cycloaddition and Aza-Michael Addition Reactions: A Diastereoselective Cascade for the Rapid Access of Pyrido[2',1':2,3]/Thiazolo[2',3':2,3]imidazo[1,5

Autor: Vunnam, Srinivasulu, Monther, Khanfar, Hany A, Omar, Raafat, ElAwady, Scott McN, Sieburth, Anusha, Sebastian, Dana M, Zaher, Farah, Al-Marzooq, Fatema, Hersi, Taleb H, Al-Tel
Rok vydání: 2019
Předmět:
Zdroj: The Journal of organic chemistry. 84(22)
ISSN: 1520-6904
Popis: The design and synthesis of a quality compound library containing a small number of skeletally diverse scaffolds, whose members rapidly deliver new chemical probes active against multiple phenotypes, is paramount in drug discovery. In this context, an efficient one-pot strategy for the synthesis of a mini library of sp
Databáze: OpenAIRE