Identification of scavenger receptor B1 as the airway microfold cell receptor for
| Autor: | Haaris S, Khan, Vidhya R, Nair, Cody R, Ruhl, Samuel, Alvarez-Arguedas, Jorge L, Galvan Rendiz, Luis H, Franco, Linzhang, Huang, Philip W, Shaul, Jiwoong, Kim, Yang, Xie, Ron B, Mitchell, Michael U, Shiloh |
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| Rok vydání: | 2019 |
| Předmět: |
Mice
Inbred BALB C Microbiology and Infectious Disease Mouse Mycobacterium tuberculosis respiratory system Nose Scavenger Receptors Class B bacterial infections and mycoses Type VII secretion system scavenger receptor Mice Immunology and Inflammation Gene Expression Regulation EsxA mucosal immunology Cell Line Tumor Adenoids Type VII Secretion Systems Animals Humans microfold cell Research Article Human |
| Zdroj: | eLife |
| ISSN: | 2050-084X |
| Popis: | Mycobacterium tuberculosis (Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we show that M cell transcytosis depends on the Mtb Type VII secretion machine and its major virulence factor EsxA. We identify scavenger receptor B1 (SR-B1) as an EsxA receptor on airway M cells. SR-B1 is required for Mtb binding to and translocation across M cells in mouse and human tissue. Together, our data demonstrate a previously undescribed role for Mtb EsxA in mucosal invasion and identify SR-B1 as the airway M cell receptor for Mtb. |
| Databáze: | OpenAIRE |
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