| Autor: |
S, Fotiou, A, Tserkezoglou, G, Hadjieleftheriou, N, Apostolikas, I, Karydas, K, Stravolemos |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
Anticancer research. 18(1B) |
| ISSN: |
0250-7005 |
| Popis: |
The purpose of this study was to evaluate the underlying pathology in breast cancer patients treated with tamoxifen who present with abnormal bleeding. A total of 56 cases were studied and the histopathologic features of 50 curettage and 18 laparotomy specimens were reviewed. All patients were under tamoxifen treatment (10-40 mg daily) for a period ranging from 5 months to 15 years. Cervical and endometrial polyps were the most common finding in the D and C material (44%). Hyperplasia was the most frequent feature identified at hysterectomy, often combined with leiomyomas, adenomyosis and ovarian tumors. Five primary adenocarcinomas of the endometrium, most of them Stage I beta, Grade I minimally invading, were found as well. These data support the hypothesis that tamoxifen exerts a proliferative estrogen-like effect on the uterus. Abnormal bleeding in women under TAM treatment warrants prompt investigation and careful follow up of the patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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