SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases
| Autor: | Robert S, Freeman, Daphne M, Hasbani, Elizabeth A, Lipscomb, Jennifer A, Straub, Liang, Xie |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Neurons
Molecular Sequence Data Procollagen-Proline Dioxygenase Nuclear Proteins Hypoxia-Inducible Factor 1 alpha Subunit Hypoxia-Inducible Factor-Proline Dioxygenases Immediate-Early Proteins DNA-Binding Proteins Multigene Family Animals Humans Amino Acid Sequence Hypoxia-Inducible Factor 1 Caenorhabditis elegans Proteins Sequence Alignment Signal Transduction Transcription Factors |
| Zdroj: | Molecules and cells. 16(1) |
| ISSN: | 1016-8478 |
| Popis: | Key to the transduction of signals from the environment to the cell nucleus are enzymes that post-translationally modify proteins. Modifications such as protein phosphorylation have long been known to regulate protein interactions, stability, and localization, as well as enzyme activity. Recent investigations into how cells respond to varying oxygen levels have identified a new mechanism for regulating signal transduction involving the post-translational hydroxylation of proline. The enzymes that catalyze this reaction comprise a novel family of prolyl hydroxylases, which include a growth-factor-responsive and cell-death-related protein (SM-20) in mammals, and a protein (EGL-9) in C. elegans important for normal egg laying. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink