| Autor: |
C, Bologa, D, Drugărin, Z, Simon |
| Rok vydání: |
1995 |
| Předmět: |
|
| Zdroj: |
Roumanian archives of microbiology and immunology. 54(1-2) |
| ISSN: |
1222-3891 |
| Popis: |
Binding of large series of nonapeptides to the HLA-A2.1 molecule was studied by a group of Sette in order to predict strongly binding peptides with possible therapeutic interest. Here we establish QSAR-s for these series. The MTD-method was used for steric requirements concerning amino acidic side chains as well as side chain hydrophobicities. Binding of these peptides to the HLA-A2.1 molecule is favored by a lipophylic character of side chains for the anchor position 2 and 9 and for positions 1,3 and 6 and by steric features that allow predictions for some modified amino acidic residues in these positions that should increase the peptide-HLA-molecule affinity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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