Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses
| Autor: | L K, Selin, M Y, Lin, K A, Kraemer, D M, Pardoll, J P, Schneck, S M, Varga, P A, Santolucito, A K, Pinto, R M, Welsh |
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| Rok vydání: | 2000 |
| Předmět: |
Mice
Inbred BALB C Muromegalovirus Staining and Labeling Immunodominant Epitopes Receptors Antigen T-Cell alpha-beta H-2 Antigens Epitopes T-Lymphocyte Vaccinia virus CD8-Positive T-Lymphocytes Major Histocompatibility Complex Mice Inbred C57BL Interferon-gamma Mice Virus Diseases Immunoglobulin G Animals Lymphocytic choriomeningitis virus Histocompatibility Antigen H-2D Antigens Viral Dimerization Immunologic Memory Pichinde virus Cell Line Transformed |
| Zdroj: | Immunity. 11(6) |
| ISSN: | 1074-7613 |
| Popis: | Using a variety of techniques, including limiting dilution assays (LDA), intracellular IFNgamma assays, and Db-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells specific to a previously encountered virus. We also show that a prior history of a virus infection can alter the hierarchy of the immunodominant peptide response to a second virus and that virus infections selectively reactivate memory T cells with distinct specificities to earlier viruses. These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime. |
| Databáze: | OpenAIRE |
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