Tumor suppression by p21WAF1
| Autor: | Y Q, Chen, S C, Cipriano, J M, Arenkiel, F R, Miller |
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| Rok vydání: | 1995 |
| Předmět: | |
| Zdroj: | Cancer research. 55(20) |
| ISSN: | 0008-5472 |
| Popis: | The p21WAF1 gene encodes a cyclin-dependent kinase inhibitor and mediates tumor suppressor gene p53-induced cell cycle arrest. To directly test whether p21WAF1 can act as a tumor suppressor, we have expressed the p21WAF1 cDNA in several human tumor cell lines using a tetracycline-inducible system. Overexpression of p21WAF1 suppresses proliferation and soft agar growth of tumor cells in vitro, as well as tumorigenicity in vivo. Our data provide direct evidence for the tumor-suppressive activity of p21WAF1. |
| Databáze: | OpenAIRE |
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