Peripheral blood level alterations of TIMP-1, MMP-2 and MMP-9 in patients with type 1 diabetes

Autor:	P R, Maxwell, P M, Timms, S, Chandran, D, Gordon
Rok vydání:	2001
Předmět:	Adult Glycated Hemoglobin Male Tissue Inhibitor of Metalloproteinase-1 Adolescent Systole Blood Pressure Middle Aged Diabetes Mellitus Type 1 Matrix Metalloproteinase 9 Diastole Reference Values Albuminuria Humans Matrix Metalloproteinase 2 Female Matrix Metalloproteinase 1
Zdroj:	Diabetic medicine : a journal of the British Diabetic Association. 18(10)
ISSN:	0742-3071
Popis:	To determine the plasma levels of enzymes and inhibitors involved in extracellular matrix turnover in patients with Type 1 diabetes with normal renal function.Plasma levels of matrix metalloproteinases 2 and 9 (MMP-2, MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) were measured in 43 Type 1 diabetic subjects and age- and sex-matched controls.No significant difference in plasma MMP-2 between diabetic patients and controls was observed. MMP-9 was detected in the plasma of 15 diabetic patients (35%), but undetectable in all control subjects (P0.015). Plasma TIMP-1 concentrations were significantly elevated (P0.001) in diabetic patients compared to controls. There was no correlation observed between MMP-2, MMP-9 and TIMP-1 and similarly between MMP-2, MMP-9 and TIMP-1 and age, duration of diabetes, blood pressure and glycated haemoglobin (HbA1c).This study has demonstrated alterations in several plasma extracellular matrix modulators in the absence of significant vascular disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b0fcf470f0276e641cc4d5c479d34db2 https://pubmed.ncbi.nlm.nih.gov/11678966 Zobrazit plný text záznamu Plný text