Novel Class of Colony-Stimulating Factor 1 Receptor Kinase Inhibitors Based on an

Autor:	Zhicheng, Xie, Bing, Wu, Yingqiang, Liu, Wenming, Ren, Linjiang, Tong, Caigui, Xiang, Aihuan, Wei, Yuanzhuo, Gao, Limin, Zeng, Hua, Xie, Wei, Tang, Youhong, Hu
Rok vydání:	2020
Předmět:	Inflammation Lipopolysaccharides Molecular Structure Pyridines Anti-Inflammatory Agents Receptor Macrophage Colony-Stimulating Factor Rats Sprague-Dawley Small Molecule Libraries Mice Structure-Activity Relationship RAW 264.7 Cells Alkynes Animals Female Protein Kinase Inhibitors
Zdroj:	Journal of medicinal chemistry. 63(3)
ISSN:	1520-4804
Popis:	Colony-stimulating factor 1 receptor (CSF-1R) is involved in inflammatory disorders as well as in many types of cancer. Based on high-throughput screening and docking results, we performed a detailed structure-activity-relationship study, leading to the discovery of a new series of compounds with nanomolar IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b0c9850d9a29e2086e3787f1af93ab7d https://pubmed.ncbi.nlm.nih.gov/31934767 Zobrazit plný text záznamu