[Role of polymorphous genes of xenobiotic biotransformation system in pathogenesis of occupational allergic dermatoses]

Autor:	L P, Kuz'mina, N I, Izmerova, M M, Koliaskina
Rok vydání:	2011
Předmět:	Epoxide Hydrolases Male Polymorphism Genetic Middle Aged Prognosis Polymerase Chain Reaction Xenobiotics Cytochrome P-450 Enzyme System Dermatitis Occupational Case-Control Studies Dermatitis Allergic Contact Humans Female Alleles Biotransformation Aged Glutathione Transferase
Zdroj:	Meditsina truda i promyshlennaia ekologiia. (7)
ISSN:	1026-9428
Popis:	Studying genetic polymorphism of xenogiotics biotransformation system genes in patients with occupational allergic dermatoses, the authors revealed reliably higher percentage of polymorphous variants of CYP 1A1 *2C and EPHX1 A-415G genes, if compared with reference population. Combination of 3 polymorphous variants of xenobiotics biotransformation system genes (CYP 1A1, CYP3A4, EPHX1, GSTM1 and GSTT1) is characterized by earlier development, severe course and unfavorable prognosis of occupational skin condition.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b0b8ca5b29cf6438c3f8846abaefd56e https://pubmed.ncbi.nlm.nih.gov/21938920 Zobrazit plný text záznamu