Synthesis of the functionalized tricyclic core of lactonamycin by oxidative dearomatization

Autor:	C, Cox, S J, Danishefsky
Rok vydání:	2000
Předmět:	Structure-Activity Relationship Indoles Drug Design Molecular Conformation Indicators and Reagents Anti-Bacterial Agents Naphthoquinones
Zdroj:	Organic letters. 2(22)
ISSN:	1523-7060
Popis:	[reaction: see text] We report in this Letter a synthesis of the densely oxygenated CDEF ring system (27) corresponding to that found in the recently discovered antibiotic lactonamycin. The key steps in the synthesis consist of an intramolecular Wessely oxidative lactonization of acid 18, followed by a hydroxyl-directed epoxidation of enol ether 21.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b07fe65afafcc0a483cf58c4ee6a4486 https://pubmed.ncbi.nlm.nih.gov/11082017 Zobrazit plný text záznamu