| Autor: |
M D, Rhoda, C, Domenget, M, Vidaud, J, Bardakdjian-Michau, P, Rouyer-Fessard, J, Rosa, Y, Beuzard |
| Rok vydání: |
1988 |
| Předmět: |
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| Zdroj: |
Biochimica et biophysica acta. 952(2) |
| ISSN: |
0006-3002 |
| Popis: |
A murine model of sickle cell disease was tested by studying the polymerization of hybrid hemoglobin tetramers between alpha mouse and human beta S or beta S Antilles chains were prepared from Hb S Antilles, which was a new sickling hemoglobin inducing a sickle cell syndrome more severe than Hb S. The hybrid molecules did not polymerize in solution, indicating that the mouse alpha chains inhibited fiber formation. Consequently, a mouse model for sickle cell disease requires the transfer and expression of both alpha and beta S or beta S Antilles genes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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