Diffusion-weighted MRI and
| Autor: | Yi-Hsiu, Chung, Ching-Fang, Yu, Shao-Chieh, Chiu, Han, Chiu, Shin-Ting, Hsu, Ching-Rong, Wu, Chung-Lin, Yang, Ji-Hong, Hong, Tzu-Chen, Yen, Fang-Hsin, Chen |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Mice Inbred BALB C Carcinoma Hepatocellular Macrophages Liver Neoplasms Dose-Response Relationship Radiation Mice Diffusion Magnetic Resonance Imaging RAW 264.7 Cells Fluorodeoxyglucose F18 Cell Line Tumor Positron-Emission Tomography Tumor Microenvironment Animals Humans Radiopharmaceuticals Cell Proliferation |
| Zdroj: | European journal of nuclear medicine and molecular imaging. 46(8) |
| ISSN: | 1619-7089 |
| Popis: | Imaging probes/biomarkers that are correlated with molecular or microenvironmental alterations in tumors have been used not only in diagnosing cancer but also in assessing the efficacy of cancer treatment. We evaluated the early response of hepatocellular carcinoma (HCC) to radiation treatment using T2-weighted magnetic resonance imaging (MRI), diffusion-weighted (DW) MRI, andOrthotopic HCC tumors were established in the right liver lobe of Balb/c mice. Mice were longitudinally scanned using T2-weighted/DW MRI andIrradiation markedly retarded tumor growth in the orthotopic HCC model and led to increaes in ADC values as early as on day 1 after irradiation. Irradiation also resulted in increases inADC values and |
| Databáze: | OpenAIRE |
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