| Autor: |
D, Debieuvre, L, Moreau, M, Coudert, C, Locher, B, Asselain, D, Coëtmeur, C, Dayen, F, Goupil, F, Martin, P, Brun, G, De Faverges, P-A, Hauss, S, Gally, B, Ben Hadj Yahia, M, Grivaux |
| Jazyk: |
francouzština |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Revue des maladies respiratoires. 36(6) |
| ISSN: |
1776-2588 |
| Popis: |
The benefit of tyrosine kinase inhibitors for patients with an EGFR wild-type non-small cell lung cancer (NSCLC) remains controversial.The survival of patients with an EGFR wild-type NSCLC who received second- or third-line erlotinib treatment was assessed using real-life data that had been collected in a prospective, national, multicenter, non-interventional cohort study.Data from 274 patients were analysed, 185 (68%) treated with erlotinib and 89 (32%) treated with supportive care only. The median overall survival was 4.2months (95% CI [3.5; 5.4]) with erlotinib, and 1.3months (95% CI [1.0; 1.8]) with supportive care. Survival rate at 3, 6, and 12months was 62%, 37%, and 17%, respectively, with erlotinib, versus 20%, 8%, et 3%, with exclusive supportive care. Significant predictive factors for longer overall survival were the presence of adenocarcinoma, and use of 1st line chemotherapy including either taxanes, pemetrexed or vinorelbine (P0.05).Erlotinib remains a valuable therapeutic option to treat inoperable locally advanced or metastatic NSCLC after failure of at least one prior chemotherapy regimen in fragile patients who are not eligible for chemotherapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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