| Autor: |
S, Hori, Y, Nakano, T A, Furukawa, M, Ogasawara, K, Katano, K, Aoki, T, Kitamura |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
American journal of reproductive immunology (New York, N.Y. : 1989). 44(5) |
| ISSN: |
1046-7408 |
| Popis: |
The preconceptional natural-killer cell (NK) activity predicts subsequent miscarriage among women with unexplained recurrent spontaneous abortion (RSA). Psycho-neuro-immuno-endocrine network has recently been proposed as a mechanism for abortions. We therefore examined which psychosocial factors influenced the NK activity among women with RSA.We measured the preconceptional NK activity of 61 women with a history two consecutive unexplained first-trimester miscarriages and no live births. We also administered semi-structured interviews and a battery of self-report questionnaires to assess their social support, personality, self-esteem and psychiatric symptoms.The preconceptional NK activity was negatively correlated with the women's neuroticism personality trait (r= -0.32, P = 0.01) and current depressive symptoms (r = -0.26, P= 0.05), and positively correlated with their self-esteem (r = 0.34, P = 0.01).In addition to several substances such as transforming-growth-factor beta and granulocyte-macrophase colony-stimulating factor, we found that low neuroticism, low depression scale score and high self-esteem contributed to high NK activity among women with RSA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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