| Autor: |
Richard, Bedlack, Sky, Kihuwa-Mani, Paul E, Barkhaus, Michael, Bereman, James B, Caress, Jesse, Crayle, Gary L, Pattee, Terry, Heiman Patterson, Paul, Wicks, Neta, Zach, Gregory T, Carter, Kristiana, Salmon |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Amyotrophic lateral sclerosisfrontotemporal degeneration. 22(7-8) |
| ISSN: |
2167-9223 |
| Popis: |
Here we use the ALSUntangled methodology to review Tamoxifen as an ALS treatment. We show that it has plausible mechanisms, a positive preclinical study, a case report and 2 small trials suggesting benefits. We show that it appears reasonably safe, though there is a small risk of developing cancer with long term use. While we cannot yet endorse this as an ALS treatment, there is enough evidence to warrant another larger ALS trial. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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