| Autor: |
Edward, Walter, Oliver R, Gibson, Michael, Stacey, Neil, Hill, Iain T, Parsons, David, Woods |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
European journal of applied physiology. 121(4) |
| ISSN: |
1439-6327 |
| Popis: |
Endurance exercise and hyperthermia are associated with compromised intestinal permeability and endotoxaemia. The presence of intestinal fatty acid-binding protein (I-FABP) in the systemic circulation suggests intestinal wall damage, but this marker has not previously been used to investigate intestinal integrity after marathon running.Twenty-four runners were recruited as controls prior to completing a standard marathon and had sequential I-FABP measurements before and on completion of the marathon, then at four and 24 h later. Eight runners incapacitated with exercise-associated collapse (EAC) with hyperthermia had I-FABP measured at the time of collapse and 1 hour later.I-FABP was increased immediately on completing the marathon (T0; 2593 ± 1373 ng·lI-FABP is a recently described biomarker whose presence in the circulation is associated with intestinal wall damage. I-FABP levels increase after marathon running and increase further if the endurance exercise is associated with EAC and hyperthermia. After EAC, I-FABP remains high in the circulation for an extended period, suggesting ongoing intestinal wall stress. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full text from SpringerLink