| Autor: |
Stefania F, Musolino, Fatima, Shatila, Grace M O, Tieman, Anna C, Masarsky, Matthew C, Thibodeau, Jeremy E, Wulff, Heather L, Buckley |
| Rok vydání: |
2022 |
| Zdroj: |
ACS omega. 7(33) |
| ISSN: |
2470-1343 |
| Popis: |
Antimicrobial photodynamic inactivation represents a promising and potentially greener alternative to conventional antimicrobials, and a solution for multidrug-resistant strains. The current study reports the development and characterization of tetra-substituted diazirine porphyrin covalently bonded to polyethylene terephthalate (PET) and its use as an antimicrobial surface. The diazirine moiety on the porphyrin was activated using a temperature of 120 °C, which initiated a C-H insertion mechanism that irreversibly functionalized the PET surface. Activation of the surface with white LED light in phosphate-buffered saline (PBS) led to singlet oxygen generation, which was detected via the degradation of 9,10-anthracenediylbis(methylene)dimalonic acid (ADMA) over time. The bactericidal effect of the |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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