Successful treatment of metastatic extragonadal endodermal sinus (yolk sac) tumor in childhood

Autor:	W J, Thomas, J F, Kelleher, B, Duval-Arnould
Rok vydání:	1981
Předmět:	Male Spinal Neoplasms Adolescent Infant Antineoplastic Agents Vinblastine Mediastinal Neoplasms Bleomycin Doxorubicin Mesonephroma Humans Drug Therapy Combination Female Cisplatin Neoplasm Metastasis
Zdroj:	Cancer. 48(11)
ISSN:	0008-543X
Popis:	Two children with metastatic extragonadal endodermal sinus tumor who had failed VAC chemotherapy were treated with combination chemotherapy consisting of cis-platinum, vinblastine, doxorubicin HCl (Adriamycin) and bleomycin (cis-VAB). There was a complete response in both patients with one child remaining tumor-free 3 1/2 years after metastasis and 2 1/2 years after stopping therapy. The main toxic reactions encountered were associated with the use of cis-platinum, but these were manageable and resolved upon completion of therapy. Cis-VAB appears to be a safe and effective regimen for the treatment of metastatic endodermal sinus tumor. A study of the efficacy of cis-VAB in a larger group of children with endodermal sinus tumor of poor prognosis seems indicated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::afa46eb4c37268c638593bd9fd2e9d3f https://pubmed.ncbi.nlm.nih.gov/6170420 Zobrazit plný text záznamu Plný text