| Autor: |
Emma S, Chambers, Milica, Vukmanovic-Stejic, Carolin T, Turner, Barbara B, Shih, Hugh, Trahair, Gabriele, Pollara, Evdokia, Tsaliki, Malcolm, Rustin, Tom C, Freeman, Neil A, Mabbott, Mahdad, Noursadeghi, Adrian R, Martineau, Arne N, Akbar |
| Rok vydání: |
2020 |
| Zdroj: |
Immunotherapy advances. 1(1) |
| ISSN: |
2732-4303 |
| Popis: |
Ageing is associated with increased number of infections, decreased vaccine efficacy and increased systemic inflammation termed inflammageing. These changes are reflected by reduced recall responses to varicella zoster virus (VZV) challenge in the skin of older adults. Vitamin D deficiency is more common in the old and has been associated with frailty and increased inflammation. In addition, vitamin D increases immunoregulatory mechanisms and therefore has the potential to inhibit inflammageing.We investigated the use of vitamin DVitamin D insufficient older adults (We showed that older adults had reduced VZV-specific cutaneous immune response and increased non-specific inflammation as compared to young. Increased non-specific inflammation observed in the skin of older adults negatively correlated with vitamin D sufficiency. We showed that vitamin DVitamin D |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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