[Value of 123I-MIBG scanning, neuron-specific enolase and serum ferritin in the diagnosis and follow-up of patients with neuroblastoma]
| Autor: | I, Hervás Benito, A, Rivas Sánchez, P, Bello Arques, A, Cañete, J M, Fernández, A, Saura Quiles, P, González Cabezas, J C, Ruiz Rodríguez, V, Castell, J L, Pérez Pastor, J A, Monfort, A, Mateo Navarro |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Ganglioneuroblastoma Adrenal Gland Neoplasms Infant Combined Modality Therapy Mediastinal Neoplasms Iodine Radioisotopes 3-Iodobenzylguanidine Neuroblastoma Treatment Outcome Predictive Value of Tests Child Preschool Phosphopyruvate Hydratase Ferritins Biomarkers Tumor Humans Female Retroperitoneal Neoplasms Child Radionuclide Imaging |
| Zdroj: | Revista espanola de medicina nuclear. 20(5) |
| ISSN: | 0212-6982 |
| Popis: | The neuroblastoma (NB) is one of the most common pediatric malignant neoplasms. The most commonly used tumor markers in the diagnosis and follow-up of this tumor are the serum neuron-specific enolase (NSE), ferritin and lactic dehydrogenase and urinary vanillymandelic and homovanillic acid. The common imaging modalities are CT, MRI and 123I or 131I-meta-iodobenzylguanidine scintigraphy.The aim of this study is to assess the value of 123I-meta-iodobenzylguanidine (MIBG) scintigraphy and serum determinations of NSE and ferritin in the diagnosis and evolution of NB patients.20 patients (8 female, 12 male) whose ages ranged from 2 months to 9 years with a mean age of 2.64 years diagnosed of NB. 47 123I-MIBG scans, 47 NSE determinations and 47 ferritin ones were selected.At the time of diagnosis, 100% of the 123I-MIBG scans were positive. 65% of NSE determinations presented clearly pathological levels and 15% were very near to the cut-off point. Only 45% of the ferritin levels were increased. The differences between the lesions visible by 123I-MIBG scanning before and 3 months after treatment as well as NSE and ferritin levels were studied. When the Student's T test was applied, we found statistically significant pre and post-treatment differences in 123I-MIBG scanning and NSE. In the case of ferritin, there was no statistical significance in spite of the decrease in the values. The direct correlation and Spearman correlation between laboratory data and 123I-MIBG scanning as well as correlation between NSE and ferritin were also studied. There was a good correlation between 123I-MIBG and NSE and between NSE and ferritin. We have also studied the data in 7 relapses.123I-MIBG scintigraphy and serum determination of NSE are two successful diagnostic tools for the diagnosis and evolution of NB patients. |
| Databáze: | OpenAIRE |
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