| Autor: |
S S, Dalvi, V K, Nayak, S M, Pohujani, N K, Desai, N A, Kshirsagar, K C, Gupta |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
The Journal of the Association of Physicians of India. 42(6) |
| ISSN: |
0004-5772 |
| Popis: |
The effect of single oral dose of 1 gm gugulipid was studied on bioavailability of single oral dose of propranolol (40 mg) and diltiazem (60 mg) in 10 and 7 normal healthy male volunteers respectively. It was a randomised within group crossover study. Blood samples were collected at hourly intervals upto 8 hrs. Gugulipid significantly reduced (P.01) peak plasma concentration (Cmax) and area under curve (AUC 0-8 hrs) of both the drugs in normal volunteers. Such interaction in patients receiving propanolol or diltiazem with gugulipid may lead to diminished efficacy or nonresponsiveness due to significant reduction in bioavailability. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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