| Autor: |
Giovane R, Sousa, David, Pober, Alfonso, Galderisi, HuiJuan, Lv, Liping, Yu, Alexandre C, Pereira, Alessandro, Doria, Mikhail, Kosiborod, Myra A, Lipes |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Circulation. 139(6) |
| ISSN: |
1524-4539 |
| Popis: |
Poor glycemic control is associated with increased risk of cardiovascular disease (CVD) in type 1 diabetes mellitus (T1DM); however, little is known about mechanisms specific to T1DM. In T1DM, myocardial injury can induce persistent cardiac autoimmunity. Chronic hyperglycemia causes myocardial injury, raising the possibility that hyperglycemia-induced cardiac autoimmunity could contribute to long-term CVD complications in T1DM.We measured the prevalence and profiles of cardiac autoantibodies (AAbs) in longitudinal samples from the DCCT (Diabetes Control and Complications Trial) in participants with mean hemoglobin AApart from HbAPoor glycemic control is associated with cardiac autoimmunity in T1DM. Furthermore, cardiac AAb positivity is associated with an increased risk of CVD decades later, suggesting a role for autoimmune mechanisms in the development of CVD in T1DM, possibly through inflammatory pathways. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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