[Papillary carcinoma arising from dyshormonogenetic goiter]

Autor:	R, Kallel, L, Mnif Hachicha, M, Mnif, B, Hammami, L, Ayadi, I, Bahri, A, Ghorbel, M, Abid, S, Makni, T, Boudawara
Jazyk:	francouzština
Rok vydání:	2009
Předmět:	Male Thyroid Hormones Hyperplasia Adolescent Goiter Thyroid Gland Carcinoma Papillary Diagnosis Differential Cell Transformation Neoplastic Lymphatic Metastasis Mutation Congenital Hypothyroidism Thyroidectomy Humans Thyroid Neoplasms
Zdroj:	Annales d'endocrinologie. 70(6)
ISSN:	2213-3941
Popis:	Dyshormonogenetic goiter is a genetically determined thyroid hyperplasia due to an enzyme defect in thyroid-hormone synthesis. Malignant transformation is one of the most serious complications, rarely reported in the literature.We report a new case of a 13-year-old boy with goitrous hypothyroidism who consulted for a voluminous goiter. Total thyroidectomy was performed. Histopathological examination revealed multiple foci of papillary carcinoma with a lymph node metastasis.Dyshormonogenetic goiter is a rare entity, representing one of the causes of congenital hypothyroidism. It is morphologically characterized by architectural and cellular pleomorphism that may mimic thyroid malignancy and cause difficulties in differential diagnosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::aef33ce16e72a109bc9f9c53564ec0d9 https://pubmed.ncbi.nlm.nih.gov/19880092 Zobrazit plný text záznamu Full Text from ScienceDirect