| Autor: |
Sayeh, Heidari Nejad, Ryusuke, Takechi, Benjamin J, Mullins, Corey, Giles, Alexander N, Larcombe, Dean, Bertolatti, Krassi, Rumchev, Satvinder, Dhaliwal, John, Mamo |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Journal of applied toxicology : JAT. 35(1) |
| ISSN: |
1099-1263 |
| Popis: |
Epidemiological studies indicate that exposure to diesel exhaust (DE) is associated with vascular-based disorders. To investigate the effect of DE on blood-brain barrier (BBB) function and integrity, 8-week-old BALB/c mice were randomized to DE in a cyclical treatment regimen over a 2-week period. Functional integrity of BBB was determined by considering brain parenchymal abundance of IgG within the hippocampal formation and cortex at 6 h and 24 h intervals following final exposure treatment. Neurovascular inflammation was expressed as the abundance of glial fibrillar acidic protein. Two doses of DE were studied and compared to air-only treated mice. Mice exposed to DE had substantially greater abundance of parenchymal IgG compared to control mice not exposed to DE. Increased parenchymal glial fibrillar acidic protein at 24 h post-DE exposure suggested heightened neurovascular inflammation. Our findings are proof-of-concept that inhalation of DE can compromise BBB function and support the broader contention that DE exposure may contribute to neurovascular disease risk. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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