| Autor: |
Xiongjuan, Li, Biqiang, Zhou, Han, Yang, Xinping, Yang, Zhao, Zhao, Zhenglong, Pan, Xinran, Liao, Wenling, Jian, Yuqiang, Liu, Han, Lu, Qingsheng, Xue, Yan, Luo, Buwei, Yu, Huansen, Huang, Daqing, Ma, Zhiheng, Liu |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Mediators of inflammation. 2022 |
| ISSN: |
1466-1861 |
| Popis: |
A rat hyperalgesia model was induced using an intraplantar injection of Freund's complete adjuvant (FCA) or an intrathecal injection of IL-6. Mechanical allodynia was evaluated using von Frey filament tests after intrathecal injections of T-5224 (c-Fos/AP-1 inhibitor), minocycline (Mino, a specific microglia inhibitor), L-2-aminoadipic acid (LAA, an astroglial toxin), PKCT-5224, Mino, and LAA attenuated FCA- or IL-6-mediated inflammatory pain, with a decrease in c-Fos, GFAP, Iba-1, PKCSTAT3 phosphorylation at Ser 727 and the interaction with PKC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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