Autophagy Blockage Reduces the Incidence of Pancreatic Ductal Adenocarcinoma in the Context of Mutant

Autor: Laura, Mainz, Mohamed A F E, Sarhan, Sabine, Roth, Ursula, Sauer, Katja, Maurus, Elena M, Hartmann, Helen-Desiree, Seibert, Andreas, Rosenwald, Markus E, Diefenbacher, Mathias T, Rosenfeldt
Rok vydání: 2021
Zdroj: Frontiers in cell and developmental biology. 10
ISSN: 2296-634X
Popis: Macroautophagy (hereafter referred to as autophagy) is a homeostatic process that preserves cellular integrity. In mice, autophagy regulates pancreatic ductal adenocarcinoma (PDAC) development in a manner dependent on the status of the tumor suppressor gene
Databáze: OpenAIRE