| Autor: |
O A, Pliasunova, I N, Egoricheva, N V, Fediuk, A G, Pokrovskiĭ, L A, Baltina, Iu I, Murinov, G A, Tolstikov |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
Voprosy virusologii. 37(5-6) |
| ISSN: |
0507-4088 |
| Popis: |
The anti-HIV activity of beta-glycyrrhizic acid (GA) and various derivatives was studied using various strains of HIV-1 and HIV-2 in primary infected lymphoblastoid cells MT-4 and monocyte cell line U-973 chronically infected with HIV-1 and containing provirus (GKV 4005). Beta-glycyrrhizic acid and its derivatives were shown to effectively inhibit HIV-1 reproduction in MT-4 cells. The antiviral effect of beta-GA sodium salt exceeded that of AZT in cells GKV 4005. The selective indices for some GA salts were evaluated, namely: 53 for 1NH4 salt of GA, 6.7 for 1K-2Li salt of GA; 4.45 for GA. The mechanism of GA action is discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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