[Evoked retinal and cortical potentials in children with advanced and resistant retinoblastoma after neoadjuvant polychemotherapy and superselective intra-arterial chemotherapy]
| Autor: | M V, Zueva, I V, Tsapenko, S V, Saakian, O G, Panteleeva, A A, Zharua, L S, Orlovskaia |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Comparative Effectiveness Research Retinal Neoplasms Retinoblastoma Infant Antineoplastic Agents Neoadjuvant Therapy Retina Drug Resistance Neoplasm Child Preschool Electroretinography Evoked Potentials Visual Humans Infusions Intra-Arterial Female Drug Monitoring Photic Stimulation Neoplasm Staging |
| Zdroj: | Vestnik oftalmologii. 130(5) |
| ISSN: | 0042-465X |
| Popis: | Electrophysiological examinations (in accordance with the ISCEV Standards and original protocols) were performed after neoadjuvant chemotherapy or before and after superselective intra-arterial chemotherapy (SIACT) in 18 children aged 1-3 years with either newly diagnosed advanced retinoblastoma (8 eyes) or resistant retinoblastoma (14 eyes). The most considerable decrease in amplitude was demonstrated by the cone response b-wave, photopic 24 Hz flicker electroretinogram (ERG), photopic negative response, and the P1-component of multifocal ERG, indicating a significant dysfunction of bipolar and ganglion cells, more pronounced in the macular zone. After the SIACT, central retinal functions improved. In eyes with retinoblastoma there is a moderate peak latency shortening of the flash visual evoked potential (VEP) P2-component, which reflects functional changes in the central retina rather than those in the visual pathways, and therefore, flash VEP analysis is a useful tool of chemotherapy patient monitoring, especially when electroretinography cannot be performed. |
| Databáze: | OpenAIRE |
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