CXC Chemokine Receptors in the Tumor Microenvironment and an Update of Antagonist Development

Autor: Yang, Xun, Hua, Yang, Jiekai, Li, Fuling, Wu, Fang, Liu
Rok vydání: 2020
Předmět:
Zdroj: Reviews of physiology, biochemistry and pharmacology. 178
ISSN: 0303-4240
Popis: Chemokine receptors, a diverse group within the seven-transmembrane G protein-coupled receptor superfamily, are frequently overexpressed in malignant tumors. Ligand binding activates multiple downstream signal transduction cascades that drive tumor growth and metastasis, resulting in poor clinical outcome. These receptors are thus considered promising targets for anti-tumor therapy. This article reviews recent studies on the expression and function of CXC chemokine receptors in various tumor microenvironments and recent developments in cancer therapy using CXC chemokine receptor antagonists.
Databáze: OpenAIRE