| Autor: |
M E, Marshall, M L, Cibull, T, Pearson, C, Hall, S E, Goldblum |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Journal of biological response modifiers. 9(3) |
| ISSN: |
0732-6580 |
| Popis: |
Treatment with human recombinant interleukin-2 (rIL-2) is associated with multiple organ dysfunctions, including hepatic and cardiac toxicities. We present a rabbit model that may be highly suited to investigations of these organ toxicities. Rabbits were treated with rIL-2 at a dose of 3 x 10(6) Cetus units/kg/day in divided doses every 8 h for 9-11 doses. Control animals received either excipient or 5% dextrose in water. Treatment with rIL-2 resulted in hepatic and myocardial infiltration by lymphocytes and mononuclear cells. Monoclonal antibody-staining techniques revealed a high percentage of T lymphocytes. It remains to be shown whether these infiltrates are responsible for the respective organ toxicities or represent merely an epiphenomenon of rIL-2 treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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