| Autor: |
Hirokazu, Doi, Ryuji, Sakakibara, Mitsutoshi, Sato, Shigekazu, Hirai, Tohru, Masaka, Masahiko, Kishi, Yohei, Tsuyusaki, Akihiko, Tateno, Fuyuki, Tateno, Osamu, Takahashi, Tsuyoshi, Ogata |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Movement disorders : official journal of the Movement Disorder Society. 29(4) |
| ISSN: |
1531-8257 |
| Popis: |
The objective of this work was to perform an open trial of the effects of nizatidine (NZT), a selective histamine H2-receptor antagonist and a cholinomimetic, on gastroparesis in Parkinson's disease (PD) patients, using objective parameters given by a gastric emptying study using a (13) C-sodium acetate expiration breath test.Twenty patients with PD were enrolled in the study. There were 13 men and 7 women; aged 68.0 ± 7.72 years; disease duration 5.50 ± 3.62 years. All patients underwent the breath test and a gastrointestinal questionnaire before and after 3 months of administration of NZT at 300 mg/day. Statistical analysis was performed by Student t test.NZT was well tolerated by all patients and none had abdominal pain or other adverse effects. NZT significantly shortened Tmax ((13) C) (the peak time of the (13) C-dose-excess curve) (P 0.05).Although this is a pilot study, we found a significant shortening of gastric emptying time after administration of NZT in PD patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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