| Popis: |
48 patients between one and seventeen years of age were stimulated with GRF (1-29) NH2. Seventeen of them showed a constitutional delay in growth and puberty, twenty-three suffered from growth-hormone deficiency (GHD) and eight had a suspected GHD as a result of pharmacological tests. Although the results demonstrate a high specificity for GH release in children with constitutional delay of growth and patients with functioning hypophyseal gland, the sensitivity for diagnosis of GHD was poor. The majority of GHD patients suffer from hypothalamic disorders and therefore respond to GRF. In conclusion, the GRF-stimulation test may be sufficient for differentiation of hypophyseal or hypothalamic disorders. However, GRF-stimulation test shows too many false positive results in hypothalamic growth disorders and therefore is not recommended for diagnosis of GHD. |
