Identification and modulatory activity assessment of 2-hydroxy-3,4,6-trimethoxyacetophenone isolated from croton anisodontus müll. Arg.(euphorbiaceae)

Autor:	Maria T A, Oliveira, Alexandre M R, Teixeira, Henrique D M, Coutinho, Irwin R A, Menezes, Diniz M, Sena, Hélcio S, Santos, Bruna M, de Mesquita, Maria R J R, Albuquerque, Paulo N, Bandeira, Raimundo, Braz-Filho
Rok vydání:	2014
Předmět:	Acetophenones Croton Microbial Sensitivity Tests Anti-Bacterial Agents
Zdroj:	Natural product communications. 9(5)
ISSN:	1934-578X
Popis:	The n-hexane extract of the stem bark of Croton anisodontus yielded 2-hydroxy-3,4,6-trimethoxyacetophenone, a well-known substance, but isolated from this species for the first time. The antimicrobial and modulatory activities of the compound towards Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, C. krusei and C. tropicalis strains were assessed. Antibiotics such as amikacin, gentamicin and neomycin were used in a sub-inhibitory concentration. Significant activity was observed towards P. aeruginosa and S. aureus 358, with p0.001 in association with amikacin. The present results place C anisodontus as an alternative source of 2-hydroxy-3,4,6-trimethoxyacetophenone with antibacterial potential.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::adeb7feb12d257cb3a2db5bfd8aa6b50 https://pubmed.ncbi.nlm.nih.gov/25026716 Zobrazit plný text záznamu