A new parenteral emulsion for the administration of taxol

Autor:	B D, Tarr, T G, Sambandan, S H, Yalkowsky
Rok vydání:	1987
Předmět:	Mice Alkaloids Paclitaxel Chemistry Pharmaceutical Animals Emulsions Infusions Parenteral Pharmaceutical Vehicles Hemolysis Triacetin Triglycerides
Zdroj:	Pharmaceutical research. 4(2)
ISSN:	0724-8741
Popis:	Taxol (NSC-125973) is a poorly soluble plant product that exhibits excellent antimitotic properties. This study involves the development of a new formulation for taxol. The stability of taxol in a 50% triacetin emulsion as well as possible methods of intravenous administration of this dosage form was examined. A stable emulsion was found at taxol concentrations of 10 and 15 mg/ml of emulsion. The 50% triacetin emulsion showed an intravenous LD50 of 1.2 ml/kg in Swiss-Webster mice. The 10 mg/ml taxol formulation was demonstrated to be stable upon addition to 5% dextrose iv fluids provided that small packing systems were used. The taxol-triacetin emulsion can also be intravenously injected at various rates, and it may prove to be a useful formulation for taxol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::add356363ed04522f8eacbb33a28aaaf https://pubmed.ncbi.nlm.nih.gov/2908138 Zobrazit plný text záznamu Full text from SpringerLink