Studies on pyrazine derivatives. XXXIII. Synthesis and tuberculostatic activity of 1-[1-(2-pyrazinyl)-ethyl]-4-N-substituted thiosemicarbazide derivatives

Autor: B, Milczarska, H, Foks, J, Sokołowska, M, Janowiec, Z, Zwolska, Z, Andrzejczyk
Rok vydání: 2000
Předmět:
Zdroj: Acta poloniae pharmaceutica. 56(2)
ISSN: 0001-6837
Popis: Hydrogenation of 4-N-substituted thiosemicarbazonic acid acetylpyrazine derivatives with NaBH4 in dry ethanol led to seventeen new compounds. The in vitro tuberculostatic activity investigations of the 15 synthesized compound were carried out. MIC few of i.v. compounds were lower than 32 micrograms/cm3.
Databáze: OpenAIRE