| Autor: |
Makoto, Matsushita, Tsutomu, Irino, Hitomi, Kase, Kiyoshi, Kamiyama, Tsugikazu, Komoda |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Rinsho byori. The Japanese journal of clinical pathology. 55(1) |
| ISSN: |
0047-1860 |
| Popis: |
Intestinal alkaline phosphatase (IAP) isozymes in the healthy human sera appears in two isoforms: normal-molecular-weight IAP (NIAP) and high-molecular-weight IAP (HIAP). We have demonstrated that the reference range for ALP activity is higher in blood group B and O secretors than in the other blood groups, for the appearance of these isoforms is depended on blood group B or O secretors. We currently reported that blood groups dependent hyperphosphatasemia in healthy subjects only appeared in blood group B or O secretors. In the present paper, we examined estimation of blood groups dependent hyperphosphatasemia in healthy subjects by use of agarose gel electrophoresis. We classified 104 healthy subjects with the B or O secretors into two groups of blood groups dependent hyperphosphatasemia (n = 5) and normal ALP activity (n = 99). The mean HIAP percentage in blood groups dependent hyperphosphatasemia group (18.5%) was higher than that in normal ALP activity group (9.9%). These results suggested that blood groups dependent hyperphosphatasemia in healthy subjects can be estimated from the HIAP levels by agarose gel electrophoresis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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