Curcumin Improves Keratinocyte Proliferation, Inflammation, and Oxidative Stress through Mediating the SPAG5/FOXM1 Axis in an
| Autor: | Quan, Chen, Yi, Tang, Huiyan, Deng, Bihua, Liang, Huaping, Li, Zhenjie, Li, Huilan, Zhu, Lezi, Chen |
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| Rok vydání: | 2022 |
| Předmět: |
Inflammation
Keratinocytes Curcumin Kelch-Like ECH-Associated Protein 1 Interleukin-6 NF-E2-Related Factor 2 Superoxide Dismutase Tumor Necrosis Factor-alpha Forkhead Box Protein M1 Interleukin-18 NF-kappa B Cell Cycle Proteins Oxygen Oxidative Stress Matrix Metalloproteinase 9 Cyclooxygenase 2 Humans Photosensitivity Disorders Matrix Metalloproteinase 1 Reactive Oxygen Species Cell Proliferation bcl-2-Associated X Protein |
| Zdroj: | Disease markers. 2022 |
| ISSN: | 1875-8630 |
| Popis: | Chronic actinic dermatitis (CAD) is an abnormally proliferating photoallergic skin disease. Dysregulated inflammation and oxidative stress are the immediate factors in the abnormal proliferation of keratinocytes. This study aimed to investigate the effect of curcumin on the aberrant proliferation of keratinocytes in anThe keratinocytes were irradiated with ultraviolet (UV) to construct anCurcumin weakened UV-mediated inflammation, proliferation, and oxidative stress and impaired apoptosis in keratinocytes. UV boosted SPAG5/FOXM1 expression in cells, while curcumin concentration-dependently retarded SPAG5/FOXM1 expression. Overexpression of SPAG5/FOXM1 fostered UV-mediated inflammation, proliferation, oxidative stress, and intensified apoptosis, whereas curcumin mostly reversed the SPAG5/FOXM1-mediated effects. In addition, knocking down SPAG5/FOXM1 ameliorated UV-mediated keratinocyte dysfunction, whereas curcumin failed to exert further protective effects in cells with knockdown of SPAG5/FOXM1.Curcumin modulated proliferation, inflammation, oxidative stress, and apoptosis of keratinocytes by restraining the SPAG5/FOXM1 axis. |
| Databáze: | OpenAIRE |
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