The selective oestrogen receptor modulator, bazedoxifene, mimics the neuroprotective effect of 17β-oestradiol in diabetic ischaemic stroke by modulating oestrogen receptor expression and the MAPK/ERK1/2 signalling pathway

Autor: María C, Burguete, Teresa, Jover-Mengual, Mikahela A, López-Morales, Alicia, Aliena-Valero, María, Jorques, Germán, Torregrosa, Enrique, Alborch, María, Castelló-Ruiz, Juan B, Salom
Rok vydání: 2019
Předmět:
Zdroj: Journal of neuroendocrinologyREFERENCES. 31(8)
ISSN: 1365-2826
Popis: Because neuroprotection in stroke should be revisited in the era of recanalisation, the present study analysed the potential neuroprotective effect of the selective oestrogen receptor modulator, bazedoxifene acetate (BZA), in an animal model of diabetic ischaemic stroke that mimics thrombectomy combined with adjuvant administration of a putative neuroprotectant. Four weeks after induction of diabetes (40 mg kg
Databáze: OpenAIRE
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